Reciprocal carbonyl–carbonyl interactions in small molecules and proteins

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Applications of the ProteOn GLH Sensor Chip: Interactions Between Proteins and Small Molecules

Of the available ProteOn sensor chips, the GLH chip offers the highest ligand binding capacity, making it optimal for the study of protein-small molecule interactions. This higher capacity is attained through the structure of its surface binding layer, comprising a unique formula of modified polysaccharides. Higher binding capacity, together with efficient preservation of the protein’s biologic...

"Drug-like Small molecules: Configuration and their interactions with proteins studied by NMR"

Max-Planck Institute for Biophysical Chemistry: NMR-based Structural Biology and Theoretical Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany; Department of Chemistry and Biochemistry/SSPPS, 6100A/B Pacific Hall, MC 0358, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 920930358, USA; Faculty of Agriculture and Lifescience, Hirosaki University, 3-Bunkyo-Cho, Hir...

Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules.

Here we report the first example of the use of supramolecular hydrogels to discover the protein targets of aggregates of small molecules.

Characterizing non-covalent nucleic acid interactions with small molecules and proteins by calorimetry

The expression or replication of genes is affected by the binding of small molecule ligands and proteins to nucleic acid sequences. Such binding events are critical for the physiological integrity of organisms and therefore are of fundamental interest to life scientists. Recently, the thermodynamics driving these interactions have also become important to pharmaceutical scientists investigating...